ea0099p555 | Reproductive and Developmental Endocrinology | ECE2024
Chouchane Karim
, Hofbauer Susanna
, Giordani Ilaria
, nathalie vionnet
, Barigou Mohammed
, Pitteloud Nelly
, Hauschild Michael
, Papadakis Georgios
Background: Klinefelter syndrome (KFS) is the most common chromosomal aberration in men, characterized by an extra-X chromosome (47, XXY). Besides the well-known reproductive defects, KFS is characterized by a 4-fold increase in metabolic syndrome, cardiovascular morbidity and mortality. The exact cause of this constellation remains unclear.Methods: Data from non-mosaic KFS adults and adolescents, evaluated in the endocrine unit of Lausanne University Ho...