Searchable abstracts of presentations at key conferences in endocrinology

ea0099p555 | Reproductive and Developmental Endocrinology | ECE2024

Klinefelter syndrome is associated with early-onset metabolic defects that are not reversed by testosterone therapy

Chouchane Karim , Hofbauer Susanna , Giordani Ilaria , nathalie vionnet , Barigou Mohammed , Pitteloud Nelly , Hauschild Michael , Papadakis Georgios

Background: Klinefelter syndrome (KFS) is the most common chromosomal aberration in men, characterized by an extra-X chromosome (47, XXY). Besides the well-known reproductive defects, KFS is characterized by a 4-fold increase in metabolic syndrome, cardiovascular morbidity and mortality. The exact cause of this constellation remains unclear.Methods: Data from non-mosaic KFS adults and adolescents, evaluated in the endocrine unit of Lausanne University Ho...